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Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis

Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers due to its aggressive and metastatic nature. PDA is characterized by a rich tumor stroma with abundant macrophages, fibroblasts, and collagen deposition that can represent up to 90% of the tumor mass. Activation of the tyrosine k...

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Pubblicato in:Front Immunol
Autori principali: Ireland, Lucy, Luckett, Teifion, Schmid, Michael C., Mielgo, Ainhoa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056881/
https://ncbi.nlm.nih.gov/pubmed/32174917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00297
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