Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis

Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers due to its aggressive and metastatic nature. PDA is characterized by a rich tumor stroma with abundant macrophages, fibroblasts, and collagen deposition that can represent up to 90% of the tumor mass. Activation of the tyrosine k...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Ireland, Lucy, Luckett, Teifion, Schmid, Michael C., Mielgo, Ainhoa
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056881/
https://ncbi.nlm.nih.gov/pubmed/32174917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00297
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