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Plk1 Regulates Activation of the Anaphase Promoting Complex by Phosphorylating and Triggering SCF(βTrCP)-dependent Destruction of the APC Inhibitor Emi1
Progression through mitosis requires activation of cyclin B/Cdk1 and its downstream targets, including Polo-like kinase and the anaphase-promoting complex (APC), the ubiquitin ligase directing degradation of cyclins A and B. Recent evidence shows that APC activation requires destruction of the APC i...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Cell Biology
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC532041/ https://ncbi.nlm.nih.gov/pubmed/15469984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-07-0598 |
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