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Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression
Through a convergence of functional genomic and proteomic studies, we identify Bora as a previously unknown cell cycle protein that interacts with the Plk1 kinase and the SCF–β-TrCP ubiquitin ligase. We show that the Bora protein peaks in G2 and is degraded by proteasomes in mitosis. Proteolysis of...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2287288/ https://ncbi.nlm.nih.gov/pubmed/18378770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200712027 |
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