Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a

The microtubule depolymerase Kif2a controls spindle assembly and dynamics and is essential for chromosome congression and segregation. Through a proteomic analysis, we identified Kif2a as a target for regulation by the Polo-like kinase Plk1. Plk1 interacts with Kif2a, but only in mitosis, in a manne...

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Bibliographic Details
Main Authors: Jang, Chang-Young, Coppinger, Judith A., Seki, Akiko, Yates, John R., Fang, Guowei
Format: Artigo
Language:Inglês
Published: Company of Biologists 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671931/
https://ncbi.nlm.nih.gov/pubmed/19351716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.044321
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