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DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement

Dynamic turnover of the spindle is a driving force for chromosome congression and segregation in mitosis. Through a functional genomic analysis, we identify DDA3 as a previously unknown regulator of spindle dynamics that is essential for mitotic progression. DDA3 depletion results in a high frequenc...

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Hlavní autoři: Jang, Chang-Young, Wong, Jim, Coppinger, Judith A., Seki, Akiko, Yates, John R., Fang, Guowei
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2315673/
https://ncbi.nlm.nih.gov/pubmed/18411309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711032
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