Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression

Through a convergence of functional genomic and proteomic studies, we identify Bora as a previously unknown cell cycle protein that interacts with the Plk1 kinase and the SCF–β-TrCP ubiquitin ligase. We show that the Bora protein peaks in G2 and is degraded by proteasomes in mitosis. Proteolysis of...

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Bibliografske podrobnosti
Main Authors: Seki, Akiko, Coppinger, Judith A., Du, Haining, Jang, Chang-Young, Yates, John R., Fang, Guowei
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2008
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2287288/
https://ncbi.nlm.nih.gov/pubmed/18378770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200712027
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