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Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora

Polo-like kinase 1 (Plk1) and Aurora A play key roles in centrosome maturation, spindle assembly, and chromosome segregation during cell division. Here we show that the functions of these kinases during early mitosis are coordinated through Bora, a partner of Aurora A first identified in Drosophila....

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Détails bibliographiques
Auteurs principaux: Chan, Eunice H. Y., Santamaria, Anna, Silljé, Herman H. W., Nigg, Erich A.
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921497/
https://ncbi.nlm.nih.gov/pubmed/18521620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00412-008-0165-5
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