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BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1
Bcl-2-interacting mediator of cell death (Bim) is a pro-apoptotic B-cell lymphoma 2 family member implicated in numerous apoptotic stimuli. In particular, Bim is required for cell death mediated by antimitotic agents, however, mitotic regulation of Bim remains poorly understood. Here, we show that t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770328/ https://ncbi.nlm.nih.gov/pubmed/23912711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.93 |
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