βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

The BimEL tumor suppressor is a potent pro-apoptotic BH3-only protein. We found that in response to survival signals BimEL was rapidly phosphorylated on three serine residues in a conserved degron, facilitating binding and degradation via the F-box protein βTrCP. Phosphorylation of the BimEL degron...

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Bibliographische Detailangaben
Hauptverfasser: Dehan, Elinor, Bassermann, Florian, Guardavaccaro, Daniele, Vasiliver-Shamis, Gaia, Cohen, Michael, Lowes, Kym, Dustin, Michael, Huang, David C. S., Taunton, Jack, Pagano, Michele
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655121/
https://ncbi.nlm.nih.gov/pubmed/19150432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.12.020
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