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βTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
The BimEL tumor suppressor is a potent pro-apoptotic BH3-only protein. We found that in response to survival signals BimEL was rapidly phosphorylated on three serine residues in a conserved degron, facilitating binding and degradation via the F-box protein βTrCP. Phosphorylation of the BimEL degron...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2655121/ https://ncbi.nlm.nih.gov/pubmed/19150432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.12.020 |
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