ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCF(βTrCP) Ubiquitin Ligase

The ubiquitin-proteasome pathway regulates gene expression through protein degradation. Here we show that the F-box protein βTrCP, the receptor component of the SCF E3 ubiquitin ligase responsible for IκBα and β-catenin degradation, is colocalized in the nucleus with ATF4, a member of the ATF-CREB b...

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Detalhes bibliográficos
Main Authors: Lassot, Irina, Ségéral, Emmanuel, Berlioz-Torrent, Clarisse, Durand, Herve, Groussin, Lionel, Hai, Tsonwin, Benarous, Richard, Margottin-Goguet, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86853/
https://ncbi.nlm.nih.gov/pubmed/11238952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.6.2192-2202.2001
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