ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCF(βTrCP) Ubiquitin Ligase

The ubiquitin-proteasome pathway regulates gene expression through protein degradation. Here we show that the F-box protein βTrCP, the receptor component of the SCF E3 ubiquitin ligase responsible for IκBα and β-catenin degradation, is colocalized in the nucleus with ATF4, a member of the ATF-CREB b...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Lassot, Irina, Ségéral, Emmanuel, Berlioz-Torrent, Clarisse, Durand, Herve, Groussin, Lionel, Hai, Tsonwin, Benarous, Richard, Margottin-Goguet, Florence
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86853/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238952/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.6.2192-2202.2001
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