PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation

Rap1GAP is a GTPase-activating protein (GAP) that specifically stimulates the GTP hydrolysis of Rap1 GTPase. Although Rap1GAP is recognized as a tumor suppressor gene and downregulated in various cancers, little is known regarding the regulation of Rap1GAP ubiquitination and degradation under physio...

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Hlavní autoři: Wang, Dejie, Zhang, Pingzhao, Gao, Kun, Tang, Yan, Jin, Xiaofeng, Zhang, Yuanyuan, Yi, Qing, Wang, Chenji, Yu, Long
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201484/
https://ncbi.nlm.nih.gov/pubmed/25329897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110296
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