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Cyclin A2-Cyclin-Dependent Kinase 2 Cooperates with the PLK1-SCF(β-TrCP1)-EMI1-Anaphase-Promoting Complex/Cyclosome Axis To Promote Genome Reduplication in the Absence of Mitosis
Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Inhibition of cyclin-dependent kinase 1 (CDK1) with the specific inhibitor RO3306 is sufficient to trigger multiple rounds of genome reduplication. We demonstrated that although anaphase-promoting complex/c...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2786869/ https://ncbi.nlm.nih.gov/pubmed/19822658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00669-09 |
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