Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes

Metronidazole (MTDZ), the drug of choice for the treatment of protozoal infections such as luminal amebiasis, is highly susceptible to colonic metabolism, which may hinder its conversion from a colon-specific prodrug to an effective anti-amebic agent targeting the entire large intestine. Thus, in an...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Kim, Wooseong, Yang, Yejin, Kim, Dohoon, Jeong, Seongkeun, Yoo, Jin-Wook, Yoon, Jeong-Hyun, Jung, Yunjin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317261/
https://ncbi.nlm.nih.gov/pubmed/28243064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S129922
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