Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery

Celecoxib, a selective cyclooxygenase-2 inhibitor, is potentially useful for the treatment of colonic diseases such as colorectal cancer and colitis. However, the cardiovascular toxicity of celecoxib limits its routine use in the clinic. Generally, colon-specific delivery of a drug both increases th...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Lee, Yonghyun, Kim, Jungyun, Kim, Wooseong, Nam, Joon, Jeong, Seongkeun, Lee, Sunyoung, Yoo, Jin-Wook, Kim, Min-Soo, Jung, Yunjin
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524528/
https://ncbi.nlm.nih.gov/pubmed/26251576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S89077
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