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Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes

Metronidazole (MTDZ), the drug of choice for the treatment of protozoal infections such as luminal amebiasis, is highly susceptible to colonic metabolism, which may hinder its conversion from a colon-specific prodrug to an effective anti-amebic agent targeting the entire large intestine. Thus, in an...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Kim, Wooseong, Yang, Yejin, Kim, Dohoon, Jeong, Seongkeun, Yoo, Jin-Wook, Yoon, Jeong-Hyun, Jung, Yunjin
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317261/
https://ncbi.nlm.nih.gov/pubmed/28243064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S129922
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