Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target

In an inflammatory state where HOCl is generated, glycine readily reacts with HOCl to produce glycine chloramine, an anti-inflammatory oxidant. Colonic delivery of celecoxib elicits anticolitic effects in a trinitrobenzene sulfonic acid-induced rat colitis model. Glycine-bearing celecoxib derivative...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Lee, Sunyoung, Lee, Yonghyun, Kim, Wooseong, Nam, Joon, Jeong, Seongkeun, Yoo, Jin-Wook, Kim, Min-Soo, Moon, Hyung Ryong, Jung, Yunjin
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535551/
https://ncbi.nlm.nih.gov/pubmed/26300626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S88543
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