Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

Piceatannol (PCT), an anti-colitic natural product, undergoes extensive Phase II hepatic metabolism, resulting in very low bioavailability. We investigated whether colon-targeted delivery of PCT could enhance anti-colitic effects and how therapeutic enhancement occurred at the molecular level. Molec...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Yum, Soohwan, Jeong, Seongkeun, Lee, Sunyoung, Nam, Joon, Kim, Wooseong, Yoo, Jin-Wook, Kim, Min-Soo, Lee, Bok Luel, Jung, Yunjin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2015
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532174/
https://ncbi.nlm.nih.gov/pubmed/26273188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S88670
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