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PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

Blocking phosphorylation of peroxisome proliferator–activated receptor (PPAR)γ at Ser(273) is one of the key mechanisms for antidiabetes drugs to target PPARγ. Using high-throughput phosphorylation screening, we here describe that Gleevec blocks cyclin-dependent kinase 5–mediated PPARγ phosphorylati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Diabetes
Hauptverfasser: Choi, Sun-Sil, Kim, Eun-Sun, Jung, Ji-Eun, Marciano, David P., Jo, Ala, Koo, Ja Young, Choi, Soo Youn, Yang, Yong Ryoul, Jang, Hyun-Jun, Kim, Eung-Kyun, Park, Jiyoung, Kwon, Hyug Moo, Lee, In Hee, Park, Seung Bum, Myung, Kyung-Jae, Suh, Pann-Ghill, Griffin, Patrick R., Choi, Jang Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314706/
https://ncbi.nlm.nih.gov/pubmed/26740599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1382
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