PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

Blocking phosphorylation of peroxisome proliferator–activated receptor (PPAR)γ at Ser(273) is one of the key mechanisms for antidiabetes drugs to target PPARγ. Using high-throughput phosphorylation screening, we here describe that Gleevec blocks cyclin-dependent kinase 5–mediated PPARγ phosphorylati...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Choi, Sun-Sil, Kim, Eun-Sun, Jung, Ji-Eun, Marciano, David P., Jo, Ala, Koo, Ja Young, Choi, Soo Youn, Yang, Yong Ryoul, Jang, Hyun-Jun, Kim, Eung-Kyun, Park, Jiyoung, Kwon, Hyug Moo, Lee, In Hee, Park, Seung Bum, Myung, Kyung-Jae, Suh, Pann-Ghill, Griffin, Patrick R., Choi, Jang Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314706/
https://ncbi.nlm.nih.gov/pubmed/26740599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1382
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