PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

Blocking phosphorylation of peroxisome proliferator–activated receptor (PPAR)γ at Ser(273) is one of the key mechanisms for antidiabetes drugs to target PPARγ. Using high-throughput phosphorylation screening, we here describe that Gleevec blocks cyclin-dependent kinase 5–mediated PPARγ phosphorylati...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Diabetes
Päätekijät: Choi, Sun-Sil, Kim, Eun-Sun, Jung, Ji-Eun, Marciano, David P., Jo, Ala, Koo, Ja Young, Choi, Soo Youn, Yang, Yong Ryoul, Jang, Hyun-Jun, Kim, Eung-Kyun, Park, Jiyoung, Kwon, Hyug Moo, Lee, In Hee, Park, Seung Bum, Myung, Kyung-Jae, Suh, Pann-Ghill, Griffin, Patrick R., Choi, Jang Hyun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Diabetes Association 2016
Aiheet:
Metabolism
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314706/
https://ncbi.nlm.nih.gov/pubmed/26740599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1382
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