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Mechanistic elucidation guided by covalent inhibitors for the development of anti-diabetic PPARγ ligands
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-regulated transcription factor that plays crucial roles in adipogenesis, lipid metabolism, and glucose homeostasis. Several PPARγ ligands possess anti-diabetic activity and they commonly inhibit the phosphorylation of PPARγ at seri...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6021786/ https://ncbi.nlm.nih.gov/pubmed/30034693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc01279e |
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