Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation

Peroxisome proliferator-activated receptor γ (PPARγ) is a major therapeutic target for the treatment of type 2 diabetes. However, the use of PPARγ-targeted drugs, such as rosiglitazone and pioglitazone, is limited owing to serious side effects caused by classical agonism. Using a rational drug disco...

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Published in:Sci Rep
Main Authors: Jang, Jun Young, Kim, Hyunsoo, Kim, Hyun-Jung, Suh, Se Won, Park, Seung Bum, Han, Byung Woo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671948/
https://ncbi.nlm.nih.gov/pubmed/31371757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47672-w
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