Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming

Phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) at Ser273 by cyclin-dependent kinase 5 (CDK5) in adipose tissue stimulates insulin resistance, but the underlying molecular mechanisms are unclear. We show here that Thrap3 (thyroid hormone receptor-associated protein 3) can dir...

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Autores principales: Choi, Jang Hyun, Choi, Sun-Sil, Kim, Eun Sun, Jedrychowski, Mark P., Yang, Yong Ryoul, Jang, Hyun-Jun, Suh, Pann-Ghill, Banks, Alexander S., Gygi, Steven P., Spiegelman, Bruce M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215181/
https://ncbi.nlm.nih.gov/pubmed/25316675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249367.114
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