PINK1 primes parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival

Mutations in PTEN-induced putative kinase 1 (PINK1) and parkin cause autosomal-recessive Parkinson’s disease through a common pathway involving mitochondrial quality control. Parkin inactivation leads to accumulation of the parkin interacting substrate (PARIS, ZNF746) that plays an important role in...

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Publicado no:Cell Rep
Main Authors: Lee, Yunjong, Stevens, Daniel A., Kang, Sung-Ung, Jiang, Haisong, Lee, Yun-Il, Ko, Han Seok, Scarffe, Leslie A., Umanah, George E., Kang, Hojin, Ham, Sangwoo, Kam, Tae-In, Allen, Kathleen, Brahmachari, Saurav, Kim, Jungwoo Wren, Neifert, Stewart, Yun, Seung Pil, Fiesel, Fabienne C., Springer, Wolfdieter, Dawson, Valina L., Shin, Joo-Ho, Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312976/
https://ncbi.nlm.nih.gov/pubmed/28122242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.090
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