PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

BACKGROUND: Mutations in PINK1 and parkin cause autosomal recessive Parkinson’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However, compelling evidence to causatively link specific PINK1/parkin depend...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Neurodegener
Päätekijät: Pirooznia, Sheila K., Yuan, Changqing, Khan, Mohammed Repon, Karuppagounder, Senthilkumar S., Wang, Luan, Xiong, Yulan, Kang, Sung Ung, Lee, Yunjong, Dawson, Valina L., Dawson, Ted M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2020
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057660/
https://ncbi.nlm.nih.gov/pubmed/32138754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00363-x
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