PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

BACKGROUND: Mutations in PINK1 and parkin cause autosomal recessive Parkinson’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However, compelling evidence to causatively link specific PINK1/parkin depend...

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發表在:Mol Neurodegener
Main Authors: Pirooznia, Sheila K., Yuan, Changqing, Khan, Mohammed Repon, Karuppagounder, Senthilkumar S., Wang, Luan, Xiong, Yulan, Kang, Sung Ung, Lee, Yunjong, Dawson, Valina L., Dawson, Ted M.
格式: Artigo
語言:Inglês
出版: BioMed Central 2020
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057660/
https://ncbi.nlm.nih.gov/pubmed/32138754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00363-x
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