PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

BACKGROUND: Mutations in PINK1 and parkin cause autosomal recessive Parkinson’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However, compelling evidence to causatively link specific PINK1/parkin depend...

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Detalles Bibliográficos
Publicado en:Mol Neurodegener
Main Authors: Pirooznia, Sheila K., Yuan, Changqing, Khan, Mohammed Repon, Karuppagounder, Senthilkumar S., Wang, Luan, Xiong, Yulan, Kang, Sung Ung, Lee, Yunjong, Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057660/
https://ncbi.nlm.nih.gov/pubmed/32138754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00363-x
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