VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease

CBL and CBL-B ubiquitin ligases play key roles in hematopoietic stem cell homeostasis and their aberrations are linked to leukemogenesis. Mutations of CBL, often genetically-inherited, are particularly common in Juvenile Myelomonocytic Leukemia (JMML), a disease that manifests early in children. JMM...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: An, Wei, Mohapatra, Bhopal C., Zutshi, Neha, Bielecki, Timothy A., Goez, Benjamin T., Luan, Haitao, Iseka, Fany, Mushtaq, Insha, Storck, Matthew D., Band, Vimla, Band, Hamid
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312291/
https://ncbi.nlm.nih.gov/pubmed/27449297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10638
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