VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease

CBL and CBL-B ubiquitin ligases play key roles in hematopoietic stem cell homeostasis and their aberrations are linked to leukemogenesis. Mutations of CBL, often genetically-inherited, are particularly common in Juvenile Myelomonocytic Leukemia (JMML), a disease that manifests early in children. JMM...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: An, Wei, Mohapatra, Bhopal C., Zutshi, Neha, Bielecki, Timothy A., Goez, Benjamin T., Luan, Haitao, Iseka, Fany, Mushtaq, Insha, Storck, Matthew D., Band, Vimla, Band, Hamid
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312291/
https://ncbi.nlm.nih.gov/pubmed/27449297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10638
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky