Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production

Alzheimer’s disease (AD) is characterized by neuronal and synaptic loss. One process that could contribute to this loss is the intracellular caspase cleavage of the amyloid precursor protein (APP) resulting in release of the toxic C-terminal 31-amino acid peptide APP-C31 along with the production of...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Poksay, Karen S., Sheffler, Douglas J., Spilman, Patricia, Campagna, Jesus, Jagodzinska, Barbara, Descamps, Olivier, Gorostiza, Olivia, Matalis, Alex, Mullenix, Michael, Bredesen, Dale E., Cosford, Nicholas D. P., John, Varghese
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309220/
https://ncbi.nlm.nih.gov/pubmed/28261092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00046
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