The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1

BACKGROUND: Leflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, the molecular mechanism of the drug remains largely unknown. We investigated the...

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Bibliographische Detailangaben
Veröffentlicht in:J Transl Med
Hauptverfasser: Moon, Su-Jin, Kim, Eun-Kyung, Jhun, Joo Yeon, Lee, Hee Jin, Lee, Weon Sun, Park, Sang-Hi, Cho, Mi-La, Min, Jun-Ki
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304395/
https://ncbi.nlm.nih.gov/pubmed/28193225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1131-x
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