The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1

BACKGROUND: Leflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, the molecular mechanism of the drug remains largely unknown. We investigated the...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Moon, Su-Jin, Kim, Eun-Kyung, Jhun, Joo Yeon, Lee, Hee Jin, Lee, Weon Sun, Park, Sang-Hi, Cho, Mi-La, Min, Jun-Ki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304395/
https://ncbi.nlm.nih.gov/pubmed/28193225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1131-x
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