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Rapamycin Loaded Solid Lipid Nanoparticles as a New Tool to Deliver mTOR Inhibitors: Formulation and in Vitro Characterization

Recently, the use of mammalian target of rapamycin (mTOR) inhibitors, in particular rapamycin (Rp), has been suggested to improve the treatment of neurodegenerative diseases. However, as Rp is a strong immunosuppressant, specific delivery to the brain has been postulated to avoid systemic exposure....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nanomaterials (Basel)
Hauptverfasser: Polchi, Alice, Magini, Alessandro, Mazuryk, Jarosław, Tancini, Brunella, Gapiński, Jacek, Patkowski, Adam, Giovagnoli, Stefano, Emiliani, Carla
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302501/
https://ncbi.nlm.nih.gov/pubmed/28335215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nano6050087
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