Ligand activated progesterone receptor B drives autophagy-senescence transition through a Beclin-1/Bcl-2 dependent mechanism in human breast cancer cells

Loss of progesterone-receptors (PR) expression is associated with breast cancer progression. Herein we provide evidence that OHPg/PR-B through Beclin-1 evoke autophagy-senescence transition, in breast cancer cells. Specifically, OHPg increases Beclin-1 expression through a transcriptional mechanism...

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發表在:Oncotarget
Main Authors: De Amicis, Francesca, Guido, Carmela, Santoro, Marta, Giordano, Francesca, Donà, Ada, Rizza, Pietro, Pellegrino, Michele, Perrotta, Ida, Bonofiglio, Daniela, Sisci, Diego, Panno, Maria Luisa, Tramontano, Donatella, Aquila, Saveria, Andò, Sebastiano
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295403/
https://ncbi.nlm.nih.gov/pubmed/27462784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10799
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