Ligand activated progesterone receptor B drives autophagy-senescence transition through a Beclin-1/Bcl-2 dependent mechanism in human breast cancer cells

Loss of progesterone-receptors (PR) expression is associated with breast cancer progression. Herein we provide evidence that OHPg/PR-B through Beclin-1 evoke autophagy-senescence transition, in breast cancer cells. Specifically, OHPg increases Beclin-1 expression through a transcriptional mechanism...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: De Amicis, Francesca, Guido, Carmela, Santoro, Marta, Giordano, Francesca, Donà, Ada, Rizza, Pietro, Pellegrino, Michele, Perrotta, Ida, Bonofiglio, Daniela, Sisci, Diego, Panno, Maria Luisa, Tramontano, Donatella, Aquila, Saveria, Andò, Sebastiano
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295403/
https://ncbi.nlm.nih.gov/pubmed/27462784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10799
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados