Progesterone Receptor B signaling Reduces Breast Cancer Cell Aggressiveness: Role of Cyclin-D1/Cdk4 Mediating Paxillin Phosphorylation

Progesterone-Receptor (PR) positivity is related with an enhanced response to breast cancer therapy, conversely cyclin D1 (CD1) is a retained marker of poor outcome. Herein, we demonstrate that hydroxyprogesterone (OHPg) through progesterone receptor B (PR-B) reduces breast cancer cell aggressivenes...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Montalto, Francesca Ida, Giordano, Francesca, Chiodo, Chiara, Marsico, Stefania, Mauro, Loredana, Sisci, Diego, Aquila, Saveria, Lanzino, Marilena, Panno, Maria Luisa, Andò, Sebastiano, De Amicis, Francesca
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721542/
https://ncbi.nlm.nih.gov/pubmed/31426542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11081201
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