A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II

Fluoroquinolones are broad-spectrum antimicrobial agents that target type II topoisomerases. Many fluoroquinolones are highly specific for bacterial type II topoisomerases and act against both DNA gyrase and topoisomerase IV. In Escherichia coli, mutations causing quinolone resistance are often foun...

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Main Authors: Gruger, Thomas, Nitiss, John L., Maxwell, Anthony, Zechiedrich, E. Lynn, Heisig, Peter, Seeber, Siegfried, Pommier, Yves, Strumberg, Dirk
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2004
主題:
Mechanisms of Resistance
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC529191/
https://ncbi.nlm.nih.gov/pubmed/15561817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4495-4504.2004
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