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Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin.

In this study, we further examined the sequence selectivity of camptothecin in mammalian topoisomerase I cDNA from human and Chinese hamster. In the absence of camptothecin, almost all the bases at the 3'-terminus of cleavage sites are T for calf thymus and wheat germ topoisomerase I. In additi...

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Bibliografische gegevens
Hoofdauteurs: Tanizawa, A, Kohn, K W, Pommier, Y
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1993
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC310631/
https://ncbi.nlm.nih.gov/pubmed/8255771
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