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Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin.

In this study, we further examined the sequence selectivity of camptothecin in mammalian topoisomerase I cDNA from human and Chinese hamster. In the absence of camptothecin, almost all the bases at the 3'-terminus of cleavage sites are T for calf thymus and wheat germ topoisomerase I. In addition, w...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Principais autores: Tanizawa, A, Kohn, K W, Pommier, Y
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1993
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310631/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8255771/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.22.5157
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