A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II

Fluoroquinolones are broad-spectrum antimicrobial agents that target type II topoisomerases. Many fluoroquinolones are highly specific for bacterial type II topoisomerases and act against both DNA gyrase and topoisomerase IV. In Escherichia coli, mutations causing quinolone resistance are often foun...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Gruger, Thomas, Nitiss, John L., Maxwell, Anthony, Zechiedrich, E. Lynn, Heisig, Peter, Seeber, Siegfried, Pommier, Yves, Strumberg, Dirk
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2004
Assuntos:	Mechanisms of Resistance
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC529191/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15561817/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.12.4495-4504.2004
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