A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II

Fluoroquinolones are broad-spectrum antimicrobial agents that target type II topoisomerases. Many fluoroquinolones are highly specific for bacterial type II topoisomerases and act against both DNA gyrase and topoisomerase IV. In Escherichia coli, mutations causing quinolone resistance are often foun...

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Bibliographische Detailangaben
Hauptverfasser: Gruger, Thomas, Nitiss, John L., Maxwell, Anthony, Zechiedrich, E. Lynn, Heisig, Peter, Seeber, Siegfried, Pommier, Yves, Strumberg, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC529191/
https://ncbi.nlm.nih.gov/pubmed/15561817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4495-4504.2004
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