A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II

Fluoroquinolones are broad-spectrum antimicrobial agents that target type II topoisomerases. Many fluoroquinolones are highly specific for bacterial type II topoisomerases and act against both DNA gyrase and topoisomerase IV. In Escherichia coli, mutations causing quinolone resistance are often foun...

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Detalhes bibliográficos
Main Authors: Gruger, Thomas, Nitiss, John L., Maxwell, Anthony, Zechiedrich, E. Lynn, Heisig, Peter, Seeber, Siegfried, Pommier, Yves, Strumberg, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529191/
https://ncbi.nlm.nih.gov/pubmed/15561817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4495-4504.2004
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