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A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II
Fluoroquinolones are broad-spectrum antimicrobial agents that target type II topoisomerases. Many fluoroquinolones are highly specific for bacterial type II topoisomerases and act against both DNA gyrase and topoisomerase IV. In Escherichia coli, mutations causing quinolone resistance are often foun...
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| Main Authors: | , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Microbiology
2004
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC529191/ https://ncbi.nlm.nih.gov/pubmed/15561817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4495-4504.2004 |
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