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Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å resolution crystal structure of the human ELL2 C-terminal domain bound to its...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5290273/ https://ncbi.nlm.nih.gov/pubmed/28134250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14076 |
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