Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription

Super elongation complex (SEC) is a positive regulator of RNA polymerase II, which is required for HIV-1 proviral transcription. AFF1/4 is the scaffold protein that recruits other components of SEC and forms dimer depending on its THD domain (TPRL with Handle Region Dimerization Domain). Here we rep...

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Publicado no:Cell Discov
Main Authors: Tang, Dan, Chen, Chunjing, Liao, Ga, Liu, Jiaming, Liao, Banghua, Huang, QingQing, Chen, Qianqian, Zhao, Jiahui, Jiang, Hui, Duan, Jinsong, Huang, Jin, Wang, Kunjie, Wang, Jiawei, Zhou, Cuiyan, Chu, Wendan, Li, Wenqi, Sun, Bo, Li, Zhonghan, Dai, Lunzhi, Fu, Xianghui, Cheng, Wei, Xue, Yuhua, Qi, Shiqian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026398/
https://ncbi.nlm.nih.gov/pubmed/32128251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-0142-6
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