Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å resolution crystal structure of the human ELL2 C-terminal domain bound to its...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Qi, Shiqian, Li, Zichong, Schulze-Gahmen, Ursula, Stjepanovic, Goran, Zhou, Qiang, Hurley, James H.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290273/
https://ncbi.nlm.nih.gov/pubmed/28134250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14076
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items