WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos

Notch signaling in the presomitic mesoderm (psm) is critical for somite formation and patterning. Here, we show that WNT signals regulate transcription of the Notch ligand Dll1 in the tailbud and psm. LEF/TCF factors cooperate with TBX6 to activate transcription from the Dll1 promoter in vitro. Muta...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Hofmann, Michael, Schuster-Gossler, Karin, Watabe-Rudolph, Masami, Aulehla, Alexander, Herrmann, Bernhard G., Gossler, Achim
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2004
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC528888/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15545628/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1248604
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