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Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation

To test the significance of cyclic Notch activity for somite formation in mice, we analyzed embryos expressing activated Notch (NICD) throughout the presomitic mesoderm (PSM). Embryos expressing NICD formed up to 18 somites. Expression in the PSM of Hes7, Lfng, and Spry2 was no longer cyclic, wherea...

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Bibliografiset tiedot
Päätekijät: Feller, Juliane, Schneider, Andre, Schuster-Gossler, Karin, Gossler, Achim
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518812/
https://ncbi.nlm.nih.gov/pubmed/18708576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.480408
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