Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation

To test the significance of cyclic Notch activity for somite formation in mice, we analyzed embryos expressing activated Notch (NICD) throughout the presomitic mesoderm (PSM). Embryos expressing NICD formed up to 18 somites. Expression in the PSM of Hes7, Lfng, and Spry2 was no longer cyclic, wherea...

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Hauptverfasser: Feller, Juliane, Schneider, Andre, Schuster-Gossler, Karin, Gossler, Achim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2008
Schlagworte:
Research Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518812/
https://ncbi.nlm.nih.gov/pubmed/18708576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.480408
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