The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 activate NOTCH1 and NOTCH2 differently in cell-base...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Tveriakhina, Lena, Schuster-Gossler, Karin, Jarrett, Sanchez M, Andrawes, Marie B, Rohrbach, Meike, Blacklow, Stephen C, Gossler, Achim
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202052/
https://ncbi.nlm.nih.gov/pubmed/30289388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40045
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