The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 activate NOTCH1 and NOTCH2 differently in cell-base...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Tveriakhina, Lena, Schuster-Gossler, Karin, Jarrett, Sanchez M, Andrawes, Marie B, Rohrbach, Meike, Blacklow, Stephen C, Gossler, Achim
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202052/
https://ncbi.nlm.nih.gov/pubmed/30289388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40045
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