Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

Our previous work has shown that antigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in poly(lactic-co-glycolic) acid (PLGA)-based nanoparticles (NPs) induce robust and durable immune responses in mice and macaques. We investigated the efficacy of these...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Kasturi, Sudhir Pai, Kozlowski, Pamela A., Nakaya, Helder I., Burger, Matheus C., Russo, Pedro, Pham, Mathew, Kovalenkov, Yevgeniy, Silveira, Eduardo L. V., Havenar-Daughton, Colin, Burton, Samantha L., Kilgore, Katie M., Johnson, Mathew J., Nabi, Rafiq, Legere, Traci, Sher, Zarpheen Jinnah, Chen, Xuemin, Amara, Rama R., Hunter, Eric, Bosinger, Steven E., Spearman, Paul, Crotty, Shane, Villinger, Francois, Derdeyn, Cynthia A., Wrammert, Jens, Pulendran, Bali
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Vaccines and Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286877/
https://ncbi.nlm.nih.gov/pubmed/27928002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01844-16
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