3M-052, a synthetic TLR-7/8 agonist induces durable HIV-1 envelope specific plasma cells and humoral immunity in non-human primates

A fundamental challenge in vaccinology is learning how to induce durable antibody responses. Live viral vaccines induce antibody responses that last a lifetime but those induced with sub-unit vaccines wane rapidly. Studies in mice and humans have established that long-lived plasma cells (LLPCs) in t...

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Publié dans:Sci Immunol
Auteurs principaux: Kasturi, Sudhir Pai, Rasheed, Mohammed Ata-Ur, Havenar-Daughton, Colin, Pham, Mathew, Legere, Traci, Sher, Zarpheen Jinnah, Kovalenkov, Yevgeny, Gumber, Sanjeev, Huang, Jessica, Gottardo, Raphael, Fulp, William, Sato, Alicia, Sawant, Sheetal, Stanfield-Oakley, Sherry, Yates, Nicole, LaBranche, Celia, Alam, S. Munir, Tomaras, Georgia, Ferrari, Guido, Montefiori, David, Wrammert, Jens, Villinger, Francois, Tomai, Mark, Vasilakos, John, Fox, Christopher B., Reed, Steven G., Haynes, Barton F., Crotty, Shane, Ahmed, Rafi, Pulendran, Bali
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8109745/
https://ncbi.nlm.nih.gov/pubmed/32561559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abb1025
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