Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

Our previous work has shown that antigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in poly(lactic-co-glycolic) acid (PLGA)-based nanoparticles (NPs) induce robust and durable immune responses in mice and macaques. We investigated the efficacy of these...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kasturi, Sudhir Pai, Kozlowski, Pamela A., Nakaya, Helder I., Burger, Matheus C., Russo, Pedro, Pham, Mathew, Kovalenkov, Yevgeniy, Silveira, Eduardo L. V., Havenar-Daughton, Colin, Burton, Samantha L., Kilgore, Katie M., Johnson, Mathew J., Nabi, Rafiq, Legere, Traci, Sher, Zarpheen Jinnah, Chen, Xuemin, Amara, Rama R., Hunter, Eric, Bosinger, Steven E., Spearman, Paul, Crotty, Shane, Villinger, Francois, Derdeyn, Cynthia A., Wrammert, Jens, Pulendran, Bali
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286877/
https://ncbi.nlm.nih.gov/pubmed/27928002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01844-16
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