Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

Our previous work has shown that antigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in poly(lactic-co-glycolic) acid (PLGA)-based nanoparticles (NPs) induce robust and durable immune responses in mice and macaques. We investigated the efficacy of these...

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Veröffentlicht in:J Virol
Hauptverfasser: Kasturi, Sudhir Pai, Kozlowski, Pamela A., Nakaya, Helder I., Burger, Matheus C., Russo, Pedro, Pham, Mathew, Kovalenkov, Yevgeniy, Silveira, Eduardo L. V., Havenar-Daughton, Colin, Burton, Samantha L., Kilgore, Katie M., Johnson, Mathew J., Nabi, Rafiq, Legere, Traci, Sher, Zarpheen Jinnah, Chen, Xuemin, Amara, Rama R., Hunter, Eric, Bosinger, Steven E., Spearman, Paul, Crotty, Shane, Villinger, Francois, Derdeyn, Cynthia A., Wrammert, Jens, Pulendran, Bali
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286877/
https://ncbi.nlm.nih.gov/pubmed/27928002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01844-16
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